Although a chemical engineer by training, Professor Rodgers has concentrated on applications of chemical engineering fundamentals to the development and better understanding of biomedical and biological systems. His specific focus uses the fundamentals of transport phenomena, mathematical modeling, thermodynamics and kinetics. His work is largely interdisciplinary and collaborative with colleagues at medical school and pharmaceutical and bioscience programs, particularly at the University of Iowa. Some of his current projects include investigating the mechanism and potential role of redox species in and at the mitochondria of cells, mathematical mass transfer analysis of dissolved gases and nutrients in bioreactors, mathematical and experimental analysis of genetically-modified beta cells for a bioartificial pancreas, development and modeling prediction of drug delivery vehicles and development of transplantable devices.
See publications on PubMed
Biglione, N., Rodgers, V.G.J, and Peeples, T.L., “Determining Design and Scale-up Parameters for Degradation of Atrazine with Suspended Pseudomonas sp. ADP in Aqueous Bioreactors”, Biotechnology Progress, in press (2008).
Wang, Y., and Rodgers, V.G.J., “Free-Solvent Model Shows Osmotic Pressure is the Dominant Factor in Limiting Flux During Protein Ultrafiltration”, Journal of Membrane Science, in press, 2008.
Ng, C. F., Schafer, F.Q., Buettner, G.R., Rodgers, V.G.J., “Cellular hydrogen peroxide removal shows dependency on effective GPx activity: Mathematical insight into observed in-vivo behavior”, Free Radical Research, 41(11) 1201 – 1211 (2007).
Tilakaratne, H. K., Andracki, M. E., Yang, B. Hunter, S. K., and Rodgers, V.G.J., “Can Myoglobin-Expression in Pancreatic Beta Cells Improve Insulin Secretion Under Hypoxia? An Exploratory Study with Transgenic Porcine Islets”, Artificial Organs, 31(7) 521-531 (2007).
Tilakaratne, H. K., Hunter, S. K., Andracki, M. E., Benda, J. A., and Rodgers, V.G.J., “Characterizing Short-Term Release and Neovascularisation Potential of Multi-Protein Growth Supplement from Alginate-Hollow Fiber Devices”, Biomaterial, 28(1), 89-98 (2007).
Buettner G.R., Ng C. F., Rodgers V.G.J., Schafer F.Q., “A New Paradigm: Manganese Superoxide Dismutase Influences the Production of H2O2 in Cells and Thereby their Biological State”, http://dx.doi.org/10.1016/j.freeradbiomed.2006.07.015, Free Radical Biology and Medicine, 41(8) 1338-1350 (2006).
Zhao, A. and Rodgers, V.G.J., “Using TEM to Couple Transient Protein Distribution and Release for PLGA Microparticles for Potential Use as Vaccine Delivery Vehicles”, Journal of Controlled Release, 113(1) 15-22 (2006).
Derjani-Bayeh, S., and Rodgers, V.G.J., “Sieving Variations Due to the Choice in Pore Size Distribution Model”, Journal of Membrane Science, 209(1) 1-17 (2002).
Yousef, M. A., Datta, R., and Rodgers, V.G.J., “Monolayer Hydration Governs Nonideality in Osmotic Pressure of Protein Solutions”, AIChE Journal, 48(6) 1301-1308 (2002).
Tilakaratne, H.K., Hunter, S.K., and Rodgers, V.G.J., “Mathematical Modeling of Myoglobin Facilitated Transport of Oxygen in Genetically Engineered Pancreatic Beta Cells”, Mathematical Biosciences, 176(2) 253-267 (2002).
Yousef, M. A., Datta, R., and Rodgers, V.G.J., “Model of Osmotic Pressure for High Concentrated Binary Protein Solutions”, AIChE Journal, 48(4), 913-917 (2002).