Dr. Huinan Liu
Assistant Professor
Department of Bioengineering, Materials Science and Engineering Program

Ph.D., 2008 Brown University

CONTACT
Office : (951) 827-2944
Fax : (951) 827-6416
e-mail : huinanliu@engr.ucr.edu
RESEARCH INTERESTS
Biomaterials guided tissue regeneration, ceramic nanoparticles, degradable polymers, nanocomposites, resorbable metals, surface treatment for medical implants and devices, controlled drug delivery, and stem cell therapy.

Our research involves design, fabrication and evaluation of novel biomaterials for tissue regeneration and controlled drug delivery. We actively explore nanomaterials and nanotechnology for medical applications. We are interested in both fundamental mechanistic research at the interface of cell and material and applied research that target specific disease or injury and develop more effective treatment. Our mission is to develop better biomaterials for tissue engineering and medical implant/device applications and to understand cell-biomaterial and tissue-biomaterial interactions in 2D and 3D. Current projects include the development of nanocomposites for cartilage regeneration, engineering biodegradable metallic implants and biomimetic interface for orthopedic applications, and biodegradable wire for nerve regeneration. Materials studied in the lab include polymer, ceramic, nanoparticles, polymer/ceramic nanocomposites and resorbable metals.

More information on the Liu Lab


HONORS AND AWARDS

  • Materials Science and Engineering C Young Researcher Award, Elsevier, Presented at TMS meeting in San Antonio, TX, 2013.
  • Scientist Development Award, American Heart Association, 2012.
  • Hellman Fellowship Award, Hellman Foundation, 2012.
  • Academic Senate Regents Faculty Fellowship Award, University of California, 2012.
  • Burroughs Wellcome Fund (BWF) Collaborative Research Travel Grant, 2012.
  • National Science Foundation BRIGE Award, 2011.
  • International Journal of Nanomedicine Merit Award, Dove Medical Press, Presented at BMES meeting in Hartford, CT, 2011.
  • MARC/SRC Faculty Travel Award, Federation of American Societies for Experimental Biology (FASEB), 2011.
  • Acta Annual Award for Primary Contributions to the Paper Published in Acta Biomaterialia, The Acta Journals, 2009.
  • Sigma Xi Outstanding Graduate Research Award for Contributions to Future Science and Technology, 2008.
  • Graduate Excellence in Materials Science (GEMS) Award, The American Ceramic Society, 2008.
  • The Joukowsky Family Foundation Outstanding Dissertation Award, Brown University, 2008.

SELECTED PUBLICATIONS

  • Cipriano AF*, De Howitt N*, Gott SC, Miller C*, Rao MP, Liu H. Bone Marrow Stromal Cell Adhesion and Morphology on Micro- and Nanopatterned Titanium. Journal of Biomedical Nanotechnology. Accepted 7/8/2013.
  • Johnson I*, Akari K*, Liu H. Nanostructured Hydroxyapatite/Poly(lactic-co-glycolic acid) (PLGA) Composite Coating for Controlling Magnesium Degradation in Simulated Body Fluid. Nanotechnology. 24(37): 375103, Epub 08/23/2013. DOI: 10.1088/0957-4484/24/37/375103. (PMID: 23975041)
  • Lock JY*, Wyatt E*, Upadhyayula S, Whall A*, Nunez V, Vullev VI, Liu H. Degradation and Antibacterial Properties of Magnesium Alloys in Artificial Urine for Potential Resorbable Ureteral Stent Applications. Journal of Biomedical Materials Research Part A. DOI: 10.1002/jbm.a.34741. Online First, 4/2/2013. (PMID: 23564415)
  • Johnson I*, Liu H. A Study on Factors Affecting the Degradation of Magnesium and A Magnesium-Yttrium Alloy for Biomedical Applications. PLOS ONE 8(6): e65603. DOI: 10.1371/journal.pone.0065603. 6/14/2013. (PMID: 23799028)
  • Guan R, Cipriano AF*, Zhao Z, Lock JY*, Tie D, Zhao T, Cui T, Liu H. Development and Evaluation of a Magnesium-Zinc-Strontium Alloy for Biomedical Applications - Alloy Processing, Microstructure, Mechanical Properties, and Biodegradation. Materials Science and Engineering: C. 33(7): 3661-3669, 2013. DOI: 10.1016/j.msec.2013.04.054. Online First, 5/3/2013.
  • Nguyen TY*, Liu H. A Review of Current Advances in Biomaterials for Neural Tissue Regeneration. Recent Patents on Biomedical Engineering. 6: 29-39, 2013.
  • Iskandar ME*, Aslani A, Liu H. The Effects of Nanostructured Hydroxyapatite Coating on the Biodegradation and Cytocompatibility of Magnesium Implants. Journal of Biomedical Materials Research Part A. 101A(8): 2340-2354, 2013. DOI: 10.1002/jbm.a.34530, Epub ahead of print, 1/28/2013. (PMID: 23359521)
  • Cipriano AF*, Zhao T, Johnson I*, Guan R, Garcia S*, Liu H. In vitro Degradation of Four Magnesium-Zinc-Strontium Alloys and Their Cytocompatibility with Human Embryonic Stem Cells. Journal of Materials Science: Materials in Medicine. 24(4): 989-1003, 2013. DOI 10.1007/s10856-013-4853-1, Online First, 1/30/2013. (PMID: 23361966)
  • Sebaa M*, Dhillon S*, Liu H. Electrochemical Deposition and Evaluation of Electrically Conductive Polymer Coating on Biodegradable Magnesium Implants for Neural Applications. Journal of Materials Science: Materials in Medicine. 24(2): 307-316, 2013. DOI: 10.1007/s10856-012-4796-y, Online First, 10/27/2012. (PMID: 23104085)
  • Sebaa M*, Nguyen TY*, Paul RK, Mulchandani A, Liu H. Graphene and Carbon Nanotube-Graphene Hybrid Nanomaterials for Human Embryonic Stem Cell Culture. Materials Letters. 92: 122-125, 2013. DOI: 10.1016/j.matlet.2012.10.035, 11/12/2012 online first.
  • Li JY, Liu H, and Huang PW. Effects of Pre-precipitation of Cr2N on Microstructures and Properties of High Nitrogen Stainless Steel. Journal of Central South University of Technology. 19(5): 1189-1195, 2012. DOI: 10.1007/s11771-012-1127-x
  • Lock JY*, Nguyen TY*, Liu H. Nanophase Hydroxyapatite and Poly(lactide-co-glycolide) Composites Promote Human Mesenchymal Stem Cell Adhesion and Osteogenic Differentiation In Vitro. Journal of Materials Science: Materials in Medicine. 23(10): 2543-2552, 2012. DOI: 10.1007/s10856-012-4709-0, July 9th, 2012 online first. (PMID: 22772475)
  • Lock JY*, Liu H. Nanotechnology Enabled Drug Delivery Systems for Bone and Cartilage Regeneration. Recent Patents on Biomedical Engineering. 5: 51-56, 2012.
  • Johnson I*, Liu H. In vitro Evaluation of Magnesium-based Metallic Biomaterials and the Need for Standardization. Biomaterials Forum. 34(4): 9-14, 2012.
  • Guan R, Johnson I*, Cui T, Zhao T, Zhao Z, Li X, and Liu H. Electrodeposition of Hydroxyapatite Coating on Mg-4.0Zn-1.0Ca-0.6Zr Alloy and In Vitro Evaluation of Degradation, Hemolysis and Cytotoxicity. Journal of Biomedical Materials Research Part A. 100A(4): 999-1015, 2012. (PMID: 22307984)
  • Johnson I*, Perchy D*, Liu H. In vitro Evaluation of the Surface Effects on Magnesium-Yttrium Alloy Degradation and Mesenchymal Stem Cell Adhesion. Journal of Biomedical Materials Research Part A. 100A(2): 477-485, 2012. Available online (DOI: 10.1002/jbm.a.33290) 29 November 2011. (PMID: 22125092)
  • Lock JY*, Liu H. Nanomaterials Enhanced Osteogenic Differentiation of Human Mesenchymal Stem Cells Similar to a Short Peptide of BMP-7. International Journal of Nanomedicine. 6: 2769-2777, 2011. (PMID: 22114505)
  • Liu H. The Effects of Surface and Biomolecules on Magnesium Degradation and Mesenchymal Stem Cell Adhesion. Journal of Biomedical Materials Research Part A. 99A(2): 249-260, 2011. Available online 16 August 2011. (PMID: 21976450)
  • Liu H and Webster TJ. Enhanced Biological and Mechanical Properties of Well-Dispersed Nanophase Ceramics in Polymer Composites: From 2D to 3D Printed Structures. Materials Science and Engineering: C. 31(2): 77-89, 2011. Available online 3 August 2010.
  • Liu H and Webster TJ. Mechanical Properties of Dispersed Ceramic Nanoparticles in Polymer Composites for Orthopedic Applications. International Journal of Nanomedicine. 5: 299-313, 2010. (PMID: 20463945)
  • Liu H and Webster TJ. Ceramic/Polymer Nanocomposites with Tunable Drug Delivery Capability at Specific Disease Sites. Journal of Biomedical Materials Research Part A. 93(3): 1180-1192, 2010. Epub ahead of print, Sep 23, 2009. (PMID: 19777574)
  • Liu H, Jiang W and Malshe A. Novel Nanostructured Hydroxyapatite Coating for Dental and Orthopedic Implants. JOM 61(9):67-69, 2009. September 2009.
  • Ergun C, Liu H and Webster TJ. Osteoblast Adhesion on Novel Machinable Calcium Phosphate/Lanthanum Phosphate Composites for Orthopedic Applications. Journal of Biomedical Materials Research Part A.. 89(3):727-733, 2009. Epub ahead of print, May 7, 2008. (PMID: 18464257)
  • Liu H, Yazici H, Ergun C and Webster TJ. An In Vitro Evaluation of the Ca/P Ratio Factor in Cytocompatibility of Nano-to-Micron Particulate Calcium Phosphates for Bone Regeneration. Acta Biomaterialia. 4(5): 1472-1479, 2008. (PMID: 18394980)* Rated as ScienceDirect Top 25 Hottest Articles
  • Ergun C, Liu H, Webster TJ, Olcay E, Yilmaz S and Sahin FC. Increased Osteoblast Adhesion on Nanoparticulate Calcium Phosphates with Higher Ca/P Ratios. Journal of Biomedical Materials Research A. 85(1): 236-241, 2008. (PMID: 17688268)


  • *indicates students under Professor Huinan Liu's supervision

    1997-2000 at www.liugroup.org




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